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KMID : 0616120230540040209
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Korean Journal of Pharmacognosy
2023 Volume.54 No. 4 p.209 ~ p.218
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Skin Health Promotion Effect of Small-molecular-weight Deer Antler Collagen
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Goo Boncheol-Leo
Song Da-Hye
Choi Yu-Jin
Oh Kyo-Nyeo
Oh Dool-Ri
Hong Ji-Ae
Kim Eun-Joung
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Abstract
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Skin aging is caused by structural changes in the extracellular matrix (ECM) due to internal and external factors. It is characterized by decreased skin moisture, increased skin roughness, increased skin wrinkles, and decreased skin elasticity. In this study, Elastase and Collagenase inhibitory activities and SOD, CAT, and GSH-Px activities were confirmed in HaCaT cells, and Collagen-I content and skin elasticity were also confirmed in response to UVB irradiation in HR-1 hairless mice. In addition, a double-blind, randomized, placebo-controlled study was conducted on the effects of oral administration of NP-2007 in 84 women. In the group that consumed NP-2007 or placebo, the amount of skin moisture, trans-epidermal water loss (TEWL), mass of skin keratin, skin asperity (Ra, Rz), eye wrinkle, and skin elasticity were checked. Compared to the placebo group, significant changes were confirmed at all-time points after 6 and 12 weeks of intake. This study was investigated the potential of oral administration of NP-2007 as a functional food material that improves skin.
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KEYWORD
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Cervus elaphus, Deer antler, Collagen, Hela cells, Skin health promotion
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